The Shanghai Protocol at Ten: Revolutionizing IVF through Ovarian Cycle Dynamics.
Shoham Z, Weissman A.
Journal of IVF-Worldwide. 2025;3(3):1-11. doi:10.46989/001c.138419
The Shanghai Protocol, also known as the Double Stimulation Protocol or DuoStim, is an in vitro fertilization (IVF) treatment that employs double ovarian stimulation within a single menstrual cycle to enhance oocyte yield. This review synthesizes randomized controlled trials and meta-analyses to evaluate the physiological basis, clinical outcomes, and applicability of the Shanghai Protocol for poor ovarian responders and oncologic patients requiring fertility preservation. The Shanghai Protocol significantly increases oocyte yield (e.g., up to 3.35 more metaphase II oocytes) and reduces treatment timelines (e.g., by ~2.5 months compared to conventional cycles), though live birth rate improvements are inconsistent due to the limited number and size of studies. Its flexibility and efficacy make it a transformative tool in assisted reproductive technologies (ART) for these patient groups. Further research is needed to standardize protocols and evaluate long-term live birth rates and oocyte competence.
Ospina-Idárraga, I. Montes-Suárez, D. Diaz-Corredor, K. Hernández
Journal of IVF-Worldwide. 2025;3(3):12-19. doi:10.46989/001c.141404
When fertility treatments using GnRH agonists fail to retrieve any eggs despite normal follicle development, all hope for that cycle isn’t lost. This case report demonstrates how a rescue protocol using hCG successfully salvaged a complete treatment failure in a 26-year-old egg donor, ultimately yielding 12 high-quality eggs and resulting in a healthy live birth for the recipient. The findings highlight a critical backup strategy that could prevent devastating cycle cancellations and optimize outcomes in fertility programs, particularly for patients who may be at higher risk due to factors like prolonged birth control use.
The Shanghai Protocol at Ten: Revolutionizing IVF through Ovarian Cycle Dynamics.
Shoham Z, Weissman A.
Journal of IVF-Worldwide. 2025;3(3):1-11. doi:10.46989/001c.138419
The Shanghai Protocol, also known as the Double Stimulation Protocol or DuoStim, is an in vitro fertilization (IVF) treatment that employs double ovarian stimulation within a single menstrual cycle to enhance oocyte yield. This review synthesizes randomized controlled trials and meta-analyses to evaluate the physiological basis, clinical outcomes, and applicability of the Shanghai Protocol for poor ovarian responders and oncologic patients requiring fertility preservation. The Shanghai Protocol significantly increases oocyte yield (e.g., up to 3.35 more metaphase II oocytes) and reduces treatment timelines (e.g., by ~2.5 months compared to conventional cycles), though live birth rate improvements are inconsistent due to the limited number and size of studies. Its flexibility and efficacy make it a transformative tool in assisted reproductive technologies (ART) for these patient groups. Further research is needed to standardize protocols and evaluate long-term live birth rates and oocyte competence.
Ospina-Idárraga, I. Montes-Suárez, D. Diaz-Corredor, K. Hernández
Journal of IVF-Worldwide. 2025;3(3):12-19. doi:10.46989/001c.141404
When fertility treatments using GnRH agonists fail to retrieve any eggs despite normal follicle development, all hope for that cycle isn’t lost. This case report demonstrates how a rescue protocol using hCG successfully salvaged a complete treatment failure in a 26-year-old egg donor, ultimately yielding 12 high-quality eggs and resulting in a healthy live birth for the recipient. The findings highlight a critical backup strategy that could prevent devastating cycle cancellations and optimize outcomes in fertility programs, particularly for patients who may be at higher risk due to factors like prolonged birth control use.
biweekly insights
